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Sep 19, - Peyronie's disease. Chief among the causes of penis pain is Peyronie's disease, an abnormal curvature of the penis usually caused by scar tissue in the tunica albuginea — the strength layer of the penis — says urologist Ryan Berglund, MD. Doctors also sometimes use a penile prosthetic to treat the condition. Jul 24, - Here are the most common causes for various types of penis pain, and the best ways to deal with what is ailing you below the belt and between.