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Most men with CF ( percent) are infertile because of a blockage or absence of the sperm canal, known as congenital bilateral absence of the vas deferens (CBAVD). The sperm never make it into the semen, making it impossible for them to reach and fertilize an egg through intercourse. BACKGROUND: Men with cystic fibrosis (CF) have bilateral absence of the vas with in vitro technology, specifically intracytoplasmic sperm injection (ICSI).